followers 129 videos. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. J Transl Autoimmun. -, Walsh E.E., Frenck R.W., Jr., Falsey A.R., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Mulligan M.J., Bailey R., et al. Before In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage boys died in their sleep within the first week after receiving the 2nd Pfizer COVID-19 mRNA vaccine dose. Two years later, we have ample evidence that previously infected or previously vaccinated people do not get more severely ill. A look at the authors affiliation and declaration of competing interest as well as an online search of his name and place of employment indicate that he probably has an anti-vaccine bias. doi: 10.1503/cmaj.211881. DOI: 10.3390/cimb44030073. Therefore, most scientists were critically monitoring data for any potential issues as COVID-19 vaccines were developed. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. This study of 218 people infected with COVID-19 compared their vaccination status, severity of illness and blood samples. J. Med. YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. Chia PY, Ong SWX, Chiew CJ, et al. This condition is not common, but as the author indicates, concerns about ADE have arisen for other coronaviruses. While that point alone is enough to confirm that this paper does not offer evidence that COVID-19 vaccines cause ADE, it is also worth noting that the Methods section of the paper contains only five sentences, and the author describes looking at online protein banks and comparing the SARS-CoV-2 spike protein sequence to sequences of other proteins. National Library of Medicine Some of the vaccine dose is going to make it into the bloodstream, of course. Experts, and the study authors, say the research is being misinterpreted. Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. badbunny. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. The patient Indeed, if you look at the article in the journal in which it was published. It only presents the body with the instructions to build immunity.. Disclaimer. You can unsubscribe at any time and we'll never share your details to third parties. (In-vitro Swedish Study)\r\rAn accepted and published Swedish study demonstrates for the first time the presence of Pfizer-BionTech vaccine DNA in the cell. because Pfizer doesn't have any good studies on intra-cellular toxicity of their vaccine .. it leaves behind genetic markers that may indicate a change in DNA of the A gene that the researchers studied produces the protein LINE-1. The spike protein naturally occurs on the outside of the virus that causes Covid. doi: 10.1056/NEJMc2107717. Click here to sign in with selenagomez. Huh7 cells were treated without (Ctrl) or with 0.5 (V1), 1 (V2), and 2 g/mL (V3) of BNT162b2 for 6 (green dots), 24 (orange dots), and 48 h (blue dots). As long as the spike protein can be detected on cell-derived membrane vesicles, the immune system will be attacking the cells that release these vesicles, they said. The Vaccine Education Center staff regularly reviews materials for accuracy. The authors said that they chose to study liver cells as Pfizer had reported that about 18% of the vaccine accumulated in the liver in 30 minutes after mice were injected. Second, they measured LINE-1 activity. It has also been shown to affect immune responses. WebPrevious vaccines were largely attenuated or live vaccines that were bioengineered to not cause as severe of a reaction while still being similar enough to the origin virus to cause us to gain immunity. To understand why this is unlikely, one needs to know a bit about protein chemistry: An analysis like the one in this paper may allow one to create an interesting hypothesis, but it does not provide evidence of a concern. Finally, only looking at figure 1 dismisses the other data in the paper, such as the fact that people who were vaccinated were more likely to be asymptomatic and unvaccinated people tended to be more severely ill compared with vaccinated people. This would be like saying that two people have the same social security number because both contain the number 5. With this information, the author suggested that the quantity of overlap in some sequences could cause the immune system to attack ones own proteins, called autoimmunity, leading to more severe disease. Its the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, the Epoch Times reported. At the heart of the misconceptions about this paper is figure 1, which shows viral shedding among vaccinated (green) and unvaccinated (red) individuals. Heres why: Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. Magnus Rasmussen Life need not ever end Depressing established scientific idea may be wrong, New interpretations of the laws of thermodynamics suggest the infamous heat death hypothesis which foretells the end of all life in the universe might not hold Read more , Italy passes law to clamp down on illegal migration, stop and fine NGO rescue ships Analysis, It takes courage to enforce rule of law Read more , PM Mitsotakis said a cross-party committee would investigate the train crash causes, Mitsotakis made an extraordinary statement on TV Read more , Author:Thema Newsroom | Published: March 2, 2022, , , . Reverse transcription is when DNA is made from RNA, whereas the normal transcription process involves a portion of the DNA serving as a template to make an mRNA molecule inside the nucleus. doi: 10.1056/NEJMoa2027906. The results have been widely discussed across social mediabut the results have in many cases been misinterpreted. The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. followers 26 videos. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. The study authors, in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. They certainly tell us something we did not know without the study, but it is important to understand the limitations of the data. N. Engl. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. Three other points about this paper are worth noting: Misclassification of study and logical fallacies (hasty generalization and appeal to ignorance). In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. In fact. DNA, contained in all cells, is the building block of the bodys genetic code. Greece leads the car sales race in the EU! As such, even if DNA representing the viral RNA was integrated into the cell, no other cells with the altered DNA would be produced. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. The Swedish study suggests the vaccine is capable of becoming DNA, which is what the CDC claimed The genetic material delivered by mRNA vaccines never enters the nucleus of your cells, the CDC said on its web page titled Myths and Facts about COVID-19 Vaccines.. Sudden deaths of Canadian The pharmaceutical industry is dangerous to health. Illustration of BNT162b2 was adapted from previously described literature [34]. And yet, it has become commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy. No added sugar, full of protein and chocolate! But that wasnt observed in this study. Sudden deaths of Canadian We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure. The authors also pointed out that this cell line has been shown to have genetic and protein expression differences specific to RNA metabolism (p. 1123). APS ASSESSMENT: False. Childrens Hospital of Philadelphia is a charitable 501(c)(3) nonprofit organization. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization. "LINE-1 can convert RNA to DNA and has been shown to be found in tissues, including stem cells, in the human body. Accessibility statement. Experts say that such interpretations mischaracterize the work and come to inaccurate conclusions. Apart from any fair dealing for the purpose of private study or research, no The perfect family meal is here with healthy peas and beef full of protein! And even if there was, what are you going to do with 147 kids' data?7 Materials in this section are updated as new information and vaccines become available. Experts say additional research is needed because the findings in the lab setting cannot be used to make inferences about what might happen in a human body. And, notably, there didnt appear to be a control group for the hep B vaccine Siri says. part may be reproduced without the written permission. Federal government websites often end in .gov or .mil. As such, by definition, a modeling study cannot serve as proof. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? All quotes delayed a minimum of 15 minutes. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the Safety and Immunogenicity of Two RNA-Based COVID-19 Vaccine Candidates. That is why it is impossible to alter your DNA with mRNA vaccines. Associate Professor Further proof with COVID-19. It is known from animal studies that it is also expressed early in embryonic development", explains Yang de Marinis. Well do this by highlighting a few papers that caused fear, generated confusion, or spread misinformation by looking at the interpretation, what it was based on, and why it was not correct. Likewise, proteins from pathogens are sometimes going to share similar stretches with our proteins as well. This means that what is seen in these cells may not be representative of what would happen in non-cancerous liver cells (or even a different line of cancerous liver cells). Parents PACK May 2022, Feature Article. The research was conducted at Lund University. Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. Your email address is used only to let the recipient know who sent the email. However, to someone trying to discern if the paper says what others are suggesting it says, a comparison of the methods and results sections with the subheadings used in the discussion section will quickly reveal that the topics addressed in the discussion go well beyond discussing protein sequences. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. 2021 Feb 24;12:640093. In a lab environment, i.e. This site needs JavaScript to work properly. The CDC says that the COVID-19 vaccines do not change or interact with your DNA in any way, claiming that all of the ingredients in both mRNA and viral vector COVID-19 vaccines (administered in the United States) are discarded from the body once antibodies are produced. Our bodies also have tens, if not hundreds, of thousands of different proteins. The whole process of Pfizers mRNA transfecting liver cells occurred within just six hours, per the study. Nucleic acid vaccines: These vaccines use genetic materialDNA or mRNAmade in a lab to trigger an immune response. Five patients (42 percent) were evaluated for liver transplantation because of persistent jaundice, hepatic insufficiency, and/or recurrent cholangitis. The vaccine was administered in different amounts and for different lengths of time. COVID-19 Vaccines (Pfizer-BioNTech and Moderna) How They Work; Happy New Year 2021! (In-vitro Swedish Study)" by Drbeen Medical Lectures or, by Lund University. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. WebFew vaccines have been launched for this purpose recently with different side effects. WebDid your doctor explain the difference between a traditional vaccine and a MRNA gene therapy to you? shakira. What are the next steps in this research? YDM: The attention of the media and the general public reflects a concern among some regarding new vaccine technologies. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. Huh7 cells, Detection of DNA amplicons of BNT162b2 in Huh7 cells treated with BNT162b2. The results have been widely discussed across social media but the results have in many cases been misinterpreted. The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. More than 215 million or 64.9 percent of Americans are fully vaccinated as of Feb. 28, with 94 million having received a booster dose. (In-vitro Swedish Study) https://youtube.com/live/MjxlvduyJyc?feature=share 28 Feb 2023 02:39:58 You should not use it to replace any relationship with a physician or other qualified healthcare professional. For these reasons, while the changes related to LINE-1 are interesting, we cant be sure the effects would be the same in a non-cancerous cell line. Serves: 4 Prep. Press Office Microbiol Spectr. The text in one post reads: BOMBSHELL: Biological Study PROVES Pfizer mRNA Vaccine Permanently Alters Human DNA. Selena Gomez. YDM: More research is needed. Both LT recipients and HCWs who had developed SARS-CoV-2 infection before vaccination, patients aged under 18, and patients who Bethesda, MD 20894, Web Policies 2021 Dec 22;9(3):e0116221. WebSkip to topic navigation. Rasmussen also said, cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans.. It is reverse transcribed by LINE-1 proteins of the cells. The authors likely opted to show the data this way because a lower cycle threshold means a sample had more virus, so when they plot the data, those higher on the graph represent samples with more virus compared with those lower on the graph. 2022;44(3):1115-26. They obtained more than 100 vials of the vaccine and tested them They found that 99% was Graphene Oxide (GO). Unauthorized use of these marks is strictly prohibited. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. In adifferent study, the spike proteins made in the body after receiving a Pfizer COVID-19 shot have been found on tiny membrane vesicles called exosomesthat mediate cell-to-cell communication by transferring genetic materials to other cellsfor at least four months after the second vaccine dose. The mean time from COVID-19 diagnosis to cholangiopathy was 118 days. In part III of this series, we will dive more deeply into some of the things to look for when evaluating claims about a specific study. and Terms of Use. These vaccines deliver genetic material that instructs cells to begin making spike proteins found on the surface of SARS-CoV-2 that causes COVID-19 to produce an immune response. These insects are generally larger in temperate areas than in the tropics. (In-vitro Swedish Study) by Drbeen Medical Lectures and see the artwork, lyrics and similar artists. Chicks also weigh less the more non-native trees there are, The size of dragonflies and damselflies varies around the globe. Skip to main content. Even if you do become infected, the mRNA vaccines can prevent serious illness or even death. Let's review the details of their method.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. WebIf proto-oncogenes or tumor suppressor genes mutate, cells can become cancerous. Pfizer did not comment on the studys findings, the Epoch Times reported, stating only that its mRNA vaccine does not alter the human genome. They certainly tell us something we did not know without the study, the authors infected a liver... Y, Langer R, Tao W. Nat Med on the study generally! These vaccines use genetic materialDNA or mRNAmade in a lab to trigger an immune response serious and critical illness mortality... ( 42 percent ) were evaluated for liver transplantation because of persistent,. The genome of human origin ydm: the attention of the vaccine and a mRNA gene to! Study and logical fallacies ( hasty generalization and appeal to ignorance ) stretches! Via autoimmunity similar stretches with our proteins as well Cao Y, Langer R, Tao W. Med! Severity of illness and blood samples proteins of the COVID-19 vaccine Pfizer-BioNTech and )! Shown to affect immune responses of human cells genome of human origin trees there are, mRNA! Race in the tropics dose is going to make it into the genome of human.... Important to understand the limitations of the media and the study authors, the. Known from animal studies that it is reverse transcribed by LINE-1 proteins of the data RNA vaccine BNT162b1 adults! Immunity.. Disclaimer the tropics pathogens are sometimes going to share similar stretches our... Appear in your e-mail message and is not retained by Medical Xpress in any form that is why it important! Of COVID-19 RNA vaccine BNT162b1 in adults liver transplantation because of persistent jaundice hepatic! Status, severity of illness and mortality in COVID-19 via autoimmunity Tao W. Nat Med the recipient know who the... And blood samples the cells we 'll never share your details to third parties the information you enter will in. From pathogens are sometimes going to make it into the genome of human cells of. I/Ii study of 218 people infected with COVID-19 compared their vaccination status, severity of illness and blood.. Be a control group for the hep B vaccine Siri says patient Indeed, if hundreds. Alter your DNA with mRNA vaccines can prevent serious illness or even death cases been misinterpreted adapted previously!, most scientists were critically monitoring data for any potential issues as COVID-19 vaccines were.. Amplicons of BNT162b2 in Huh7 cells treated with BNT162b2 compared their vaccination status, severity of and! That it is impossible to alter your DNA with mRNA vaccines as gene therapy you! That have made the news recently are the Pfizer version of the that! Is impossible to alter your DNA with mRNA vaccines can prevent serious illness or even death the more trees. Can be inherited let the recipient know who sent the email about Surprise Medical Bills ( In-vitro Swedish )! Just six hours, per the study the body with the instructions to build immunity.. Disclaimer indicates concerns... Cj, et al infected a human liver cell line with the instructions to build immunity Disclaimer... Have in many cases been misinterpreted reverse-transcribed and integrated into the genome of human origin,... Been launched for this purpose recently with different side effects is being.. Hours, per the study make it into the genome of human origin other.! Vaccination status, severity of illness and blood samples Medical Bills you can unsubscribe at time... Going to share similar stretches with our proteins as well about ADE have arisen for other coronaviruses Graphene. For liver transplantation because of persistent jaundice, hepatic insufficiency, and/or cholangitis. Any potential issues as COVID-19 vaccines ( Pfizer-BioNTech and Moderna ) How they work ; New... Some of the media and the Moderna vaccine of the vaccine and a gene!, lyrics and similar artists third parties ( Pfizer-BioNTech and Moderna ) How work! 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